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Why Do Humans Age?

Published in Aging Biology 3 mins read

Human aging is a complex process with no single definitive cause. Several contributing factors are widely accepted.

Leading Theories of Aging

Several theories attempt to explain why humans age:

  • Accumulated Damage: This theory posits that aging results from the gradual accumulation of damage to our cells, tissues, and DNA. This damage can stem from various sources, including:

    • Oxidative stress: The damaging effects of free radicals, unstable molecules that damage cells.
    • UV light exposure: Sun damage causes significant cellular damage and contributes to visible signs of aging.
    • Wear and tear: The constant use and stress on our bodies throughout life inevitably lead to deterioration. This is especially evident in joints and other high-stress areas.
    • Metabolic byproducts: The waste products of metabolism can accumulate and damage cells over time. This is supported by research indicating that reducing caloric intake may slow this process.
  • Genetic Programming: This theory suggests that aging is a predetermined process controlled by our genes. Our genes may contain a built-in "biological clock" that dictates the lifespan of our cells and tissues. This idea is supported by the observation of varying lifespans across different species. This theory also emphasizes that genetic variations influence an individual's susceptibility to age-related diseases.

  • Combination of Factors: Most scientists agree that aging is likely a complex interplay between both accumulated damage and genetic programming. The interplay of our genetics and environmental exposures significantly influence the aging process.

The Aging Process: A Timeline

While aging is gradual, studies suggest there might be periods of accelerated aging. Recent research indicates noticeable increases in aging occur around ages 44 and 60. These are periods where noticeable changes like wrinkles, aches and pains frequently appear.

Mitigating the Effects of Aging

While we cannot stop aging completely, lifestyle choices can influence the rate at which we age and the health of our aging bodies. These include:

  • Maintaining a healthy diet.
  • Regular exercise.
  • Protecting the skin from sun damage.
  • Managing stress.

Several studies and articles (like those from Nature, The New York Times, National Geographic and The Guardian) emphasize the ongoing research into the mechanisms of aging and the potential for interventions to slow or mitigate its effects. However, the exact "how" and "why" of human aging remain topics of ongoing scientific exploration.

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