The most extreme allergic reaction is anaphylaxis, also known as anaphylactic shock. It's a life-threatening condition that can cause a range of symptoms, including lightheadedness, difficulty breathing, and even collapse.
While anaphylaxis can be triggered by various allergens like peanuts, insect stings, and medications, it's not necessarily the rarest allergy itself. The rarity of an allergy is determined by the frequency of individuals experiencing it. For instance, aquagenic urticaria, or water allergy, is considered extremely rare. It causes itchy and painful hives when someone's skin comes into contact with water.
It's important to remember that allergies can vary significantly in severity, and even seemingly minor allergies can become life-threatening if not treated promptly.