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Defining "Human" DNA

Published in Ancient DNA 3 mins read

How Old Is Human DNA?

The oldest recovered DNA is over 1 million years old, but the oldest hominin DNA is approximately 400,000 years old. This is a crucial distinction; while DNA far older than 400,000 years exists, it hasn't yet been successfully recovered and analyzed from hominin remains. The age of human DNA itself is a complex question depending on what we mean by "human".

The age of human DNA depends on how we define "human". Are we talking about:

  • The age of the oldest Homo sapiens DNA: The oldest confirmed Homo sapiens DNA dates back approximately 300,000 to 400,000 years (Science, 2024). This is based on mitochondrial DNA (mtDNA) sequencing.
  • The age of the last common ancestor of Neanderthals and modern humans: Estimates using mtDNA suggest a last common ancestor around 550,000 to 690,000 years ago (Smithsonian Institution). This is older than the oldest Homo sapiens DNA.
  • The age of the oldest hominin DNA: This stretches back to approximately 400,000 years ago, as mentioned earlier. Beyond this point, DNA preservation becomes extremely challenging.

Challenges in Dating Ancient DNA

Analyzing ancient DNA (aDNA) presents unique hurdles. aDNA is highly degraded and fragmented, making sequencing difficult. Furthermore, contamination with modern DNA is a major concern, requiring rigorous methods to ensure the extracted DNA is authentically ancient. The oldest successfully sequenced DNA comes from mammoth molars (Wikipedia), exceeding 1 million years old. However, the successful sequencing of hominin DNA hasn't extended that far back.

Technological Advancements and Future Discoveries

Ongoing advancements in DNA sequencing technology and analysis techniques continually push the boundaries of what we can learn about ancient DNA. Future research may well unearth even older human or hominin DNA, rewriting our understanding of human evolutionary history. For example, studies have recovered human and mammalian DNA from 25,000-year-old sediment (Current Biology, 2021). This illustrates the potential for discovering ancient genetic material in unexpected sources.

The question of "how old is human DNA?" is therefore not a single definitive answer. It is dependent upon how you define “human” within an evolutionary context and is subject to continuous refinement with ongoing scientific research and improved analytical capabilities.

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