Yes, Goku can overwhelmingly defeat the Demon Slayer universe.
Based on established power scaling, even Goku from early in the Dragon Ball series (before Dragon Ball Z) possesses power far exceeding anything demonstrated in Demon Slayer.
Power Disparity
- Goku (Early Dragon Ball): Demonstrates superhuman strength, speed, and durability capable of destroying large structures and moving faster than the eye can track. His Ki attacks are also devastating.
- Demon Slayer Characters: While incredibly skilled and possessing unique abilities (Breathing Styles), Demon Slayers are ultimately limited by human physiology and weapon capabilities. Their attacks, while effective against demons, are not on the same destructive scale as Goku's.
Speed Comparison
Goku's speed in the early Dragon Ball series far surpasses that of Demon Slayer characters. Demon Slayers are fast, but Goku's ability to move faster than the eye can see is a significant advantage. This speed advantage becomes more pronounced as Goku progresses through the Dragon Ball series.
Durability
Even early in Dragon Ball, Goku's durability is extraordinary. He can withstand attacks that would instantly kill any character from Demon Slayer. Demon slayers, even the pillars, are still vulnerable to conventional weaponry to some degree.
Ki Abilities vs. Breathing Styles
Goku's ki-based attacks offer significantly more destructive power and versatility compared to the Breathing Styles utilized by Demon Slayers. Ki blasts are capable of destroying objects and opponents on a much grander scale. Breathing Styles amplify human abilities, but are limited by the physical constraints of the user.
Conclusion
The power gap between Goku and the Demon Slayer universe is vast. Even the earliest version of Goku is significantly more powerful and capable, making a victory for Goku a near certainty.