Yes, research indicates that vitamin B12 can increase alkaline phosphatase (ALP) activity under certain conditions.
How B12 Affects Alkaline Phosphatase
Studies show a concentration-dependent increase in ALP activity in certain cell types when exposed to vitamin B12. Specifically, vitamin B12 in the concentration range from 10-12 to 10-8 mol/L increased ALP activity in both human bone marrow stromal cells (hBMSC) and UMR106 cells. https://pubmed.ncbi.nlm.nih.gov/8969275/ This suggests a direct effect of B12 on ALP production in these cell types, although the mechanism isn't fully elucidated in this particular study.
It's crucial to note that elevated ALP isn't solely caused by B12. Many other factors can increase ALP levels, including liver and bone diseases. https://www.webmd.com/digestive-disorders/alkaline_phosphatase_test Conversely, low ALP can be associated with deficiencies in certain nutrients, including zinc, magnesium, and potentially vitamin B12 itself, suggesting a complex relationship. http://www.foodandnutritionjournal.org/volume5number3/low-alkaline-phosphatase-alp-in-adult-population-an-indicator-of-zinc-zn-and-magnesium-mg-deficiency/
While some studies show a positive correlation between B12 levels and ALP, others show a negative correlation or no correlation at all. Therefore, the relationship between B12 and ALP is complex and depends on various factors including the individual's overall health and the specific cellular context. https://journals.lww.com/ajg/fulltext/2015/10001/variation_of_hepatic_enzymes_with_vitamin_b12_and.2013.aspx
This information should not be interpreted as medical advice. Always consult a healthcare professional for any health concerns.
