Certain bacteria, including Bordetella pertussis and Pseudomonas aeruginosa, increase cAMP (cyclic adenosine monophosphate) concentration in target cells.
How These Bacteria Increase cAMP
These bacteria achieve this increase by secreting toxins. These toxins possess adenylyl cyclase (AC) activity. Adenylyl cyclase is an enzyme that catalyzes the conversion of ATP (adenosine triphosphate) to cAMP. By introducing AC activity into the target cell, these bacteria directly stimulate the production of cAMP. (3).
| Bacteria | Mechanism | Reference |
|---|---|---|
| Bordetella pertussis | Secretes toxin with AC activity | (3) |
| Pseudomonas aeruginosa | Secretes toxin with AC activity | (3) |
