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What is the difference between the composition of a fatty acid and an amino acid?

Published in Biochemistry Basics 2 mins read

The primary difference between the composition of a fatty acid and an amino acid lies in their functional groups and overall structure.

Fatty Acids vs. Amino Acids: A Compositional Comparison

Feature Fatty Acid Amino Acid
Main Structure Long hydrocarbon chain with a carboxyl group (-COOH) Central carbon atom bonded to an amino group (-NH2), a carboxyl group (-COOH), a hydrogen atom (-H), and a variable R-group.
Functional Groups Carboxyl group (-COOH) Amino group (-NH2), Carboxyl group (-COOH), R-group
Hydrophobicity Generally hydrophobic (water-repelling) Can be hydrophobic or hydrophilic (water-attracting), depending on the R-group.
Reference Long chain carboxylic acids that contains one carboxylic group and a long hydrophobic hydrocarbon chain Contain both carboxylic group and amino group attached to the same carbon atom. (13-Aug-2019)

Key Differences Explained

  • Fatty Acids: According to the reference, these are essentially long-chain carboxylic acids. This means they have a carboxyl group at one end and a long, hydrophobic hydrocarbon chain. The hydrophobic nature comes from the chain being composed mostly of carbon and hydrogen atoms, which don't interact well with water.

  • Amino Acids: The reference highlights that amino acids contain both a carboxyl group and an amino group attached to the same carbon atom. This central carbon (alpha carbon) is also bonded to a hydrogen atom and a unique "R-group" or side chain. The R-group is what makes each of the 20 common amino acids different, and it determines their specific chemical properties (hydrophobic, hydrophilic, acidic, basic, etc.).

In essence, while both fatty acids and amino acids contain a carboxyl group, amino acids also feature an amino group and a variable R-group, giving them a wider range of functionalities compared to the relatively simple, hydrophobic nature of fatty acids. This structural difference leads to vastly different roles in biological systems.

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