FAD has a more positive reduction potential compared to NAD+.
Because FAD has a more positive reduction potential, it is considered a stronger oxidizing agent. This means it has a greater tendency to accept electrons, leading to its own reduction and the oxidation of another molecule. This is crucial in biochemical reactions, particularly those requiring energetically demanding oxidations, such as the dehydrogenation of a C-C single bond to create an alkene. In simpler terms, FAD is more "eager" to accept electrons than NAD+, making it more effective in oxidizing other molecules.
