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What is PPI in biology?

Published in Biochemistry 1 min read

PPI stands for Protein-Protein Interaction. It refers to the physical contact between two or more protein molecules. These interactions are highly specific and are crucial for a wide range of biological processes, including:

  • Cellular signaling: Proteins interact to relay signals within and between cells.
  • Enzyme regulation: Proteins bind to enzymes to activate or inhibit their activity.
  • Structural support: Proteins form complex structures, like the cytoskeleton, providing shape and stability to cells.
  • DNA replication and repair: Proteins work together to copy and repair genetic material.

PPI data can be used to map networks of interactions on a larger scale, revealing intricate relationships between proteins within an organism. These networks can be used to understand complex biological processes and develop new drugs.


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