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Why is Blood Called Serum?

Published in Blood Component 3 mins read

Actually, blood is not called serum. Serum is a component of blood, specifically the fluid part that remains after blood cells and clotting proteins are removed. The confusion likely arises from the fact that serum is a vital part of blood.

What Exactly is Serum?

Serum is essentially plasma without the clotting factors. Here’s a breakdown:

  • Blood: Consists of red blood cells, white blood cells, platelets, and plasma.
  • Plasma: The liquid component of blood containing water, proteins, and other substances, including clotting factors like fibrinogen.
  • Serum: Plasma from which clotting factors, particularly fibrinogen, have been removed.

Etymological Origin of Serum

The word “serum” is derived from the Proto-Indo-European *ser- ("to flow, run"), referencing its liquid nature. This origin highlights the fluid aspect of serum as the component that flows, compared to the more cellular and solid portions of blood.

Why Study Serum?

Serum analysis is a cornerstone of diagnostic medicine. The absence of clotting factors makes serum the ideal fluid for various laboratory tests. Here are a few reasons why serum is valuable:

  • Clinical Diagnostics: Serum is used to measure various substances in the blood, including electrolytes, antibodies, hormones, and enzymes. This information is crucial for diagnosing and monitoring diseases.
  • Immunology: Because serum contains antibodies, it's vital for studying the body's immune response.
  • Research: Serum is often used as a sample source in biological and medical research.

Comparison Table

Feature Blood Plasma Serum
Description A bodily fluid in animals that circulates The liquid component of blood Plasma without clotting factors
Components Red blood cells, white blood cells, platelets, plasma Water, proteins, clotting factors, other substances Water, proteins, electrolytes, antibodies, hormones, and other substances
Clotting Factors Contains Contains Does not contain
Use Transport of nutrients, gases, and waste Transports substances, blood clotting Clinical tests, diagnostics, and research

Key Takeaway

Blood is a complete fluid, and serum is a part of it. Serum is not a synonym for blood, but rather a specific fraction of it without clotting components. The etymological root of "serum" emphasizing its flowing nature.

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