Yes, normal saline (isotonic saline) infusion can increase blood pressure, but this effect appears to be related to the type of saline and how it affects the body.
Based on the provided reference:
Blood pressure was increased only during the isotonic saline infusion but not during hypertonic saline administration. It is concluded that stimulation of adrenal CA secretion by saline loading is mediated through a renal factor.
This suggests that:
- Isotonic Saline (Normal Saline) Increases BP: Infusion of isotonic saline, which is what's typically referred to as "normal saline," did increase blood pressure in the study.
- Hypertonic Saline Does Not Increase BP: Interestingly, hypertonic saline infusion did not increase blood pressure in this same study.
- Renal Factor: The mechanism by which isotonic saline increases blood pressure seems to involve a "renal factor," possibly related to the adrenal catecholamine (CA) secretion.
In summary, while saline administration can affect blood pressure, the effect varies depending on the tonicity of the saline solution. Normal saline (isotonic) showed a tendency to increase blood pressure in the study, while hypertonic saline did not.
