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What is the Difference Between Total Protein and Total Solids?

Published in Blood Protein Measurement 3 mins read

Based on the provided information, total protein and total solids are used interchangeably in the context described, referring to the same measurement.

According to the reference, "Total solids (TS), also know as Total Protein (TP), is a measure of the amount of plasma proteins in the blood; these include albumin, globulins and fibrinogen." This indicates that in certain contexts, particularly when measuring in blood plasma, Total Solids (TS) is simply another name for Total Protein (TP).

Understanding Total Solids (TS) and Total Protein (TP)

When these terms are used synonymously, they represent the concentration of proteins found in the liquid part of blood (plasma or serum). These proteins are vital for many bodily functions.

Key Components Measured (when TS = TP):

  • Albumin: A major protein produced by the liver, essential for maintaining osmotic pressure and transporting various substances.
  • Globulins: A group of proteins including antibodies (immunoglobulins), transport proteins, and enzymes.
  • Fibrinogen: A protein involved in blood clotting.

Synonymous Terms in Practice

This synonymy is often observed in veterinary medicine when using a tool like a refractometer to quickly estimate protein concentration in plasma or serum. The refractometer measures the refractive index of the fluid, which is influenced by dissolved substances, including proteins. The scale on the refractometer might be labeled for "Total Solids" or "Total Protein," but in this application, they quantify the same thing: the total concentration of plasma proteins.

Comparing TS and TP (in this context)

Since the reference states they are the same, a direct comparison table looks like this:

Feature Total Solids (TS) Total Protein (TP)
Definition Amount of plasma proteins in the blood Amount of plasma proteins in the blood
Also Known As Total Protein (TP) Total Solids (TS)
Measured Components Albumin, Globulins, Fibrinogen Albumin, Globulins, Fibrinogen

Practical Application

Measuring Total Protein (or Total Solids using this terminology) is a routine screening test that can provide valuable information about an animal's hydration status, liver function (as albumin is produced by the liver), kidney function (as protein loss can occur with kidney disease), and immune status (related to globulins).

  • High TP/TS could indicate dehydration or chronic inflammation.
  • Low TP/TS could suggest malnutrition, liver disease, or protein loss through the kidneys or gut.

In summary, according to the provided reference, the difference between Total Protein and Total Solids is that there is no difference; they are two names for the same measurement in the described context.

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