LLC cells are a cell line derived from a mouse lung tumor. Specifically, they are established from the lung of a C57BL mouse bearing a tumor that resulted from an implantation of primary Lewis lung carcinoma.
Here's a breakdown:
- Origin: Lewis Lung Carcinoma (LLC)
- Organism: Mouse (C57BL strain)
- Tissue: Lung
- ATCC Number: CLR1642
- Resistance: Resistant to 1,3-bis-(2-chloroethyl)-1-nitrosourea.
- Sensitivity: Sensitive to methotrexate.
In essence, LLC cells are a valuable tool in cancer research, allowing scientists to study lung cancer in vitro and in vivo (after injection into mice). They are a well-characterized cell line with known drug sensitivities and resistances, making them useful for preclinical drug testing.
| Feature | Description |
|---|---|
| Cell Line | LLC (Lewis Lung Carcinoma) |
| Species | Mouse (C57BL) |
| Tissue of Origin | Lung |
| Tumor Origin | Resulting from the implantation of primary Lewis lung carcinoma. |
| Drug Resistance | Resistant to 1,3-bis-(2-chloroethyl)-1-nitrosourea |
| Drug Sensitivity | Sensitive to methotrexate |
