Yes, cartilage ages. The aging process affects its structure and composition.
How Cartilage Changes With Age
As we age, cartilage undergoes several changes that impact its function and health. These changes can contribute to joint pain and increase the risk of conditions like osteoarthritis. According to research, the key changes include:
- Cartilage Thinning: A gradual loss of cartilage matrix occurs with aging. The reference specifically mentions, "Cartilage thinning is consistent with a gradual loss of cartilage matrix with aging". This thinning reduces cartilage's ability to cushion and protect the joints.
- Decreased Hydration: Older cartilage tends to become less hydrated. This affects its elasticity and ability to absorb shock.
- Reduced Cellularity: The number of cells within the cartilage decreases with age. These cells are responsible for maintaining the cartilage matrix, so a reduction in their numbers compromises the tissue's ability to repair itself. The reference states, "A recent study of human femoral cartilage demonstrated an age-related decrease in cellularity...".
- Glycosaminoglycan (GAG) Loss: GAGs are important molecules that help cartilage retain water and maintain its structure. Age-related loss of GAG content weakens the tissue. The reference shows this change: "A recent study of human femoral cartilage demonstrated an age-related decrease in cellularity and glycosaminoglycan content that could contribute to weakening of the tissue."
Summary of Age-Related Cartilage Changes
| Change | Description | Impact |
|---|---|---|
| Cartilage Thinning | Loss of cartilage matrix. | Reduced cushioning and protection of joints. |
| Decreased Hydration | Less water content in cartilage. | Decreased elasticity and shock absorption. |
| Reduced Cellularity | Fewer cells in the cartilage. | Impaired ability to repair and maintain the cartilage matrix. |
| GAG Loss | Reduction in glycosaminoglycans. | Weakened tissue structure and reduced water retention. |
