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What is Cytosol vs Cytoplasm?

Published in Cell Biology 2 mins read

The terms cytosol and cytoplasm are often used interchangeably, but they refer to different components of a cell. The key distinction lies in what each term includes within the cell's boundaries. According to the Amoeba Sisters (Cytoplasm and Cytosol - Amoeba Sisters #Shorts), understanding this difference is important for accurately describing locations within a cell.

Here's a breakdown:

  • Cytoplasm: This encompasses everything inside the cell membrane but outside the nucleus (in eukaryotic cells). It includes:

    • The cytosol (the fluid portion).
    • Organelles (e.g., mitochondria, endoplasmic reticulum, Golgi apparatus).
    • Other structures like ribosomes and the cytoskeleton.
  • Cytosol: This is the fluid portion of the cytoplasm. It's the gel-like substance in which the organelles and other cellular structures are suspended. It's primarily composed of water, ions, small molecules, and macromolecules (like proteins).

Here's a table to illustrate the difference:

Feature Cytoplasm Cytosol
Definition Everything inside the cell membrane (excluding the nucleus) The fluid portion of the cytoplasm
Components Cytosol, organelles, other structures Water, ions, small molecules, macromolecules
Analogy A bowl of soup with noodles and vegetables The broth in the soup
In Eukaryotes Excludes the nucleus Excludes the nucleus

In essence, the cytosol is a part of the cytoplasm. The cytoplasm is the broader term.

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