Ska, in a medical context, refers to the spindle- and kinetochore-associated complex.
The Significance of the Ska Complex
The Spindle and Kinetochore Associated (Ska) complex plays a crucial role in cell division. Here's a breakdown:
- Essential for Anaphase: According to research, the Ska complex is vital for the normal onset of anaphase during mitosis (cell division).
- Microtubule Binding: The C-terminal domain (CTD) of Ska1, a component of the Ska complex, binds to microtubules.
- Kinetochore Movement: This binding is believed to facilitate the movement of kinetochores (structures on chromosomes) along depolymerizing spindle microtubules.
In essence, the Ska complex is a key player in ensuring accurate chromosome segregation during cell division.
