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What is the difference between cell growth and mitosis?

Published in Cell Biology 3 mins read

Cell growth and mitosis are distinct but interconnected processes within the cell cycle. Cell growth refers to an increase in a cell's size and mass, while mitosis is a specific phase involving the division of the cell’s nucleus.

Here's a more detailed breakdown:

Understanding Cell Growth and Mitosis

Feature Cell Growth Mitosis
Definition Increase in cell size and mass. This includes the synthesis of new proteins, lipids, and other macromolecules. A stage of the cell cycle where the cell nucleus divides into two identical nuclei.
Timing Occurs primarily during the interphase of the cell cycle. Occurs after interphase, as a distinct phase in the cell cycle.
Purpose To prepare the cell for division by accumulating the necessary building blocks and resources. To separate duplicated chromosomes into two new nuclei for two new daughter cells.
Outcome Larger cell, but still one cell. Two daughter cells, each with a complete and identical copy of the parent cell's genetic material.

Cell Growth in Detail

  • Interphase Focus: Cell growth is a major activity during the interphase, specifically in the G1 and G2 phases. This is where the cell increases its cytoplasm, produces organelles, and duplicates necessary proteins.
  • Preparatory: Cell growth ensures the cell has adequate resources and size to proceed to cell division. This involves metabolic activities to synthesise DNA, proteins and lipids required for cellular replication.
  • Increase in Size: It involves the overall expansion of the cell in its volume and mass.

Mitosis in Detail

  • Nuclear Division: Mitosis is focused on the division of the cell's nucleus, resulting in two nuclei that are genetically identical to the parent nucleus.
  • Phases: Mitosis is divided into several distinct phases: prophase, metaphase, anaphase, and telophase. Each has specific steps to ensure accurate separation of chromosomes.
  • Cell Division Follows: Mitosis precedes cytokinesis, the division of the cytoplasm, to create two separate daughter cells.
  • Genetic Stability: Ensures each new daughter cell receives the same genetic information as the parent cell.

Relationship Between Cell Growth and Mitosis

The reference highlights that the cell cycle encompasses cell growth and division: "A cell cycle is a series of events that takes place in a cell as it grows and divides. A cell spends most of its time in what is called interphase, and during this time it grows, replicates its chromosomes, and prepares for cell division. The cell then leaves interphase, undergoes mitosis, and completes its division."

  • Cell growth during interphase is necessary to prepare the cell for mitosis. Without sufficient growth, mitosis might be unsuccessful or result in non-viable daughter cells.
  • Mitosis is the process that divides the cell's nucleus into two. It relies on cell growth from the preceding interphase.

In summary, cell growth is a continuous process of increasing size and accumulating resources, while mitosis is a specific phase of the cell cycle focused on dividing the nucleus for the formation of new cells. Cell growth occurs mostly during interphase and precedes mitosis.

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