The cell with the least energy is a red blood cell. Red blood cells lack mitochondria, the powerhouses of the cell, and thus rely on glycolysis, a less efficient energy-producing process, to meet their energy needs. Because of this, red blood cells have a limited lifespan and are constantly being replaced by new ones.
Red blood cell enzymopathies, which are diseases affecting the enzymes within red blood cells, can further disrupt their energy production and shorten their lifespan, leading to hemolytic anemia.
