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Which Cells Cannot Be Killed by Apoptosis?

Published in Cell Death Resistance 2 mins read

Cancer cells are notably resistant to apoptosis, a process of programmed cell death.

Apoptosis, or programmed cell death, is a crucial mechanism in the body for eliminating unwanted or abnormal cells. This process involves a series of carefully orchestrated molecular steps that lead to the self-destruction of a cell. However, certain cells, particularly cancer cells, have developed mechanisms to evade apoptosis, allowing them to proliferate uncontrollably.

According to a reference from May 19, 2019, cancer cells cannot be killed by apoptosis. This is because:

  • Apoptosis is a natural cell death mechanism designed to remove cells that are damaged or no longer needed.
  • Cancer cells, however, develop resistance to these signals, effectively making them immortal.
  • This resistance allows tumors to grow and spread unchecked, a significant factor in cancer progression.

It's important to note that while apoptosis is vital for overall health, its inability to kill cancer cells underscores the challenges in cancer treatment and the need for targeted therapies that can overcome this resistance.

Understanding the mechanisms behind apoptosis and how cancer cells circumvent it is critical for developing effective cancer treatments.

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