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Can there be mitosis without DNA replication?

Published in Cell Division 1 min read

No, there cannot be mitosis without DNA replication.

Mitosis is the process of cell division where a single cell divides into two identical daughter cells. A crucial step before mitosis is DNA replication. According to provided information:

  • Mitosis Requires Chromosome Splitting: Mitosis involves the splitting of chromosomes at the centromere, which separates the replicated chromosomes.
  • Equal DNA Distribution: Without DNA replication, the DNA cannot be equally divided into two daughter cells. The end result would be daughter cells lacking the full genetic complement, or having damaged genetic information.
Feature With DNA Replication Without DNA Replication
Chromosome Splitting Possible Impossible
DNA Distribution Equal Unequal
Daughter Cells Viable Non-Viable

In essence, DNA replication ensures that each daughter cell receives a complete and identical set of genetic information. Skipping this step would lead to cells with missing or incomplete chromosomes, which are generally non-viable.

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