HTLA cells are a specific type of cell line derived from HEK293 cells, engineered for particular research applications.
Based on the provided reference, here's a breakdown:
- Origin: Derived from HEK293 cells.
- Key Features:
- Contain stable integrations of a tTA-dependent luciferase reporter.
- Contain a β-arrestin2-TEV fusion gene.
- Usage Example: They can be transiently transfected with a gene of interest, such as an AVPR2-TCS-tTA fusion gene, to study receptor activity (e.g., response to vasopressin).
In essence, HTLA cells are a valuable tool for studying receptor signaling and drug responses due to their engineered reporter system.
