Hallmark cells are large, distinctive cells characterized by their unique appearance. Histologically, these cells are large pleomorphic cells with abundant cytoplasm.
Key Characteristics of Hallmark Cells
These cells display specific features under a microscope:
- Size and Shape: They are notably large and have a variety of shapes (pleomorphic).
- Cytoplasm: The cytoplasm is abundant, meaning they have a lot of material filling the cell besides the nucleus.
- Nucleus: The nucleus is eccentric, meaning it's off-center within the cell. It is typically “horseshoe or kidney” shaped.
- Nucleoli: They often contain multiple small basophilic nucleoli (small dark-staining structures within the nucleus).
Summary Table
| Feature | Description |
|---|---|
| Size | Large |
| Shape | Pleomorphic (variable) |
| Cytoplasm | Abundant |
| Nucleus | Eccentric, “horseshoe or kidney” shaped |
| Nucleoli | Multiple small, basophilic |
Hallmark cells are identified based on these characteristics, enabling pathologists and researchers to recognize them within tissues.
