The size of keratinocytes can vary, influencing their behavior and differentiation.
According to research, the size of keratinocytes plays a crucial role in their ability to form clones and undergo differentiation. This indicates that there isn't one fixed size for all keratinocytes.
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Smaller Keratinocytes: Keratinocytes that are 11 microns or less in diameter retain the ability to form clones when isolated from human epidermis and cultured. This suggests they are less differentiated and retain proliferative potential.
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Larger Keratinocytes: Keratinocytes that are 12 microns or more in diameter are irreversibly committed to further enlargement and terminal differentiation. This means they are moving towards the end of their life cycle and are less likely to proliferate.
| Keratinocyte Size | Behavior |
|---|---|
| ≤ 11 microns | Capable of forming clones when cultured; less differentiated. |
| ≥ 12 microns | Committed to further enlargement and terminal differentiation. |
Therefore, the size of a keratinocyte isn't static; it changes as the cell differentiates. The provided data suggests a critical size range around 11-12 microns, influencing the cell's fate.
