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Can Mitosis Have Mutations?

Published in Cellular Genetics 2 mins read

Yes, mitosis can have mutations.

Mutations are changes in the DNA sequence, and while they are more commonly associated with meiosis (cell division for sexual reproduction), they can also occur during mitosis, which is cell division for growth and repair. This means that errors in DNA replication or repair during the process of mitotic cell division can introduce mutations.

How Mutations Occur During Mitosis

Several factors can lead to mutations during mitosis:

  • DNA Replication Errors: When DNA is copied before cell division, mistakes can occur, resulting in a change in the DNA sequence.
  • DNA Damage: DNA can be damaged by various factors, such as environmental chemicals (mutagens) and radiation. If this damage is not repaired properly before cell division, it can result in a mutation.
  • Exposure to Mutagens: As stated in the reference, mutagens like chemicals (e.g., inhaled while smoking) or radiation (e.g., X-rays, UV light) can cause mutations in the DNA during mitosis.

Types of Mutations

Mutations can take various forms, from single nucleotide changes to larger chromosomal alterations. These mutations can:

  • Have no noticeable effect on the cell (silent mutations).
  • Alter the function of the cell or lead to the death of the cell.
  • In some cases, if the mutation occurs in a critical gene, the mutation may cause cancerous growth.

Summary

In summary, the reference clearly states, "Mutations may also occur during mitosis and meiosis." Therefore, while often associated with meiosis, mitosis is not immune to mutations. These can arise from errors in DNA replication, DNA damage, or exposure to mutagens.

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