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What are secondary lysosomes?

Published in Cellular Organelles 1 min read

Secondary lysosomes are organelles within cells responsible for degrading materials taken in from outside the cell or from within the cell. According to the provided reference, they are formed through a specific process:

Formation of Secondary Lysosomes

Secondary lysosomes are formed when primary lysosomes fuse with phagosomes/pinosomes. They are larger than primary lysosomes and play a crucial role in cellular digestion.

Here's a breakdown of their function:

  • Formation Process:

    • A primary lysosome, containing digestive enzymes, merges with a vesicle (phagosome or pinosome) that contains material to be broken down.
    • This fusion creates the secondary lysosome.
  • Function:

    • The enzymes within the secondary lysosome digest the contents of the vesicle.
    • The resulting smaller molecules can then be used by the cell.
  • Extracellular Release:

    • Secondary lysosomes are capable of releasing their content outside the cells where they degrade foreign materials.

In summary, secondary lysosomes represent the active stage of lysosomal digestion, resulting from the fusion of primary lysosomes with vesicles containing materials targeted for degradation.

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