Reed-Sternberg (RS) cells most commonly originate from a neoplastic clone derived from B lymphocytes within the lymph node germinal centers.
Understanding Reed-Sternberg (RS) Cells and Their Origin
RS cells are large, abnormal cells characteristically found in Hodgkin Lymphoma (HL). Understanding their origin is crucial for comprehending the pathogenesis of this disease.
The B-Lymphocyte Connection
- Neoplastic Clone: RS cells arise from a single, abnormally dividing cell (a neoplastic clone).
- Germinal Center B Cells: These cells are derived from B lymphocytes that reside in the germinal centers of lymph nodes. The germinal center is where B cells normally undergo maturation and antibody diversification.
- Preapoptotic State: Many cases of HL arise from germinal center B cells that are in a preapoptotic state. This means they are programmed for cell death but, in this case, fail to die. According to the reference, most cases of HL arise from preapoptotic germinal center B cells that cannot synthesize immunoglobulin.
- Resistance to Apoptosis: The R-S cell appears to be resistant to apoptotic stimuli.
Table Summarizing RS Cell Origin
| Feature | Description |
|---|---|
| Origin | Neoplastic clone of B lymphocytes |
| Location | Lymph node germinal centers |
| Functional Defect | Often unable to synthesize immunoglobulin |
| Apoptosis Resistance | Resistant to signals that normally trigger cell death (apoptosis) |
Implications of Origin
The B-cell origin of RS cells has implications for:
- Diagnosis: Immunohistochemical markers specific to B cells are often used in the diagnosis of Hodgkin Lymphoma.
- Treatment: Understanding the cellular origin can guide the development of targeted therapies.
