Reed-Sternberg cells are distinctive, large, abnormal lymphocytes (a type of white blood cell) that are characteristic of Hodgkin lymphoma. These cells are also known as Hodgkin and Reed-Sternberg cells.
Key Characteristics of Reed-Sternberg Cells
- Large Size: They are significantly larger than typical lymphocytes.
- Abnormal Lymphocytes: They are not functioning as normal white blood cells and are instead cancerous.
- Multiple Nuclei: They often contain more than one nucleus. Sometimes, the nuclei give the appearance of "owl's eyes".
Why Are Reed-Sternberg Cells Important?
The presence of Reed-Sternberg cells in a tissue sample is crucial for diagnosing Hodgkin lymphoma. They are essentially a hallmark of this type of cancer.
Example:
If a biopsy sample from a lymph node shows the presence of these large, abnormal cells with multiple nuclei, especially with their characteristic "owl's eye" appearance, it will strongly suggest Hodgkin lymphoma.
Diagnosing Hodgkin Lymphoma:
- Biopsy: Examining a sample of affected tissue, typically from a lymph node.
- Identification: Pathologists look for the presence of Reed-Sternberg cells.
- Staging: If found, further testing determines the spread of the disease.
| Feature | Description |
|---|---|
| Cell Type | Large, abnormal lymphocyte |
| Location | Found in people with Hodgkin lymphoma |
| Nuclei | Often contain more than one nucleus; sometimes appears as “owl’s eyes” |
| Significance | Diagnostic marker for Hodgkin lymphoma |
| Synonyms | Hodgkin and Reed-Sternberg cells |
In summary, Reed-Sternberg cells are important diagnostic indicators of Hodgkin lymphoma due to their specific appearance and characteristic presence in this disease.
