Melanin is a key substance that protects keratinocytes. Specifically, it safeguards them against DNA damage induced by H2O2.
How Melanin Protects Keratinocytes
Melanin, a pigment found in our skin, plays a vital role in defending against cellular damage. Here's how it works:
- Binding Ca2+: Melanin's ability to bind calcium ions (Ca2+) is essential for its protective function.
- Protection Against H2O2: Specifically, the reference shows that melanin's binding of Ca2+ is important for protecting against hydrogen peroxide (H2O2) induced DNA strand breaks in both melanocytes and keratinocytes.
- DNA Integrity: By mitigating the effects of H2O2, melanin helps preserve the integrity of DNA in keratinocytes.
| Protective Agent | Protected Cells | Mechanism |
|---|---|---|
| Melanin | Keratinocytes, Melanocytes | Binds Ca2+ to prevent H2O2-induced DNA strand breaks |
While other factors might contribute to keratinocyte protection, the provided reference highlights the significant role of melanin, emphasizing its ability to bind to Ca2+ and prevent DNA damage from H2O2.
