Yes, cerebrospinal fluid (CSF) does contain cells.
While often perceived as a cell-free fluid, CSF actually contains a specific selection of cells. These are primarily blood-derived lymphocytes and monocytes.
Cells in CSF
- Lymphocytes: Immune cells crucial for adaptive immunity.
- Monocytes: Immune cells that can differentiate into macrophages or dendritic cells.
These cells are able to cross the blood–CSF barrier (BCSFB) located at the choroid plexus. According to the reference, this barrier allows limited entry of immune cells under normal conditions. This allows the minimal entry of immune cells and macromolecules, such as antibodies, in steady-state [6].
In summary, while CSF isn't teeming with cells, it does contain a population of lymphocytes and monocytes that contribute to immune surveillance within the central nervous system.
