No, the character known as "Joker" from Persona 5 is not a girl. He is a male character.
Joker, also known as Ren Amamiya (in the anime and manga adaptations), is the protagonist of the 2016 video game Persona 5. He is a teenage boy designed by artist Shigenori Soejima. Therefore, based on the character's design and established lore, Joker is definitively male.
