Your high HDL (High-Density Lipoprotein) cholesterol could be due to genetic factors affecting HDL production or clearance, or other underlying medical conditions.
Here's a more detailed breakdown:
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Genetics:
- CETP Gene Mutation: A mutation in the Cholesteryl Ester Transfer Protein (CETP) gene can significantly elevate HDL levels, sometimes exceeding 150 mg/dL. This gene plays a role in transferring cholesterol between lipoproteins. A mutation inhibits this transfer, leading to higher HDL.
- Other Genetic Factors: Other, less common, genetic variations can also influence HDL levels. Your body might simply be predisposed to produce more HDL or have a slower rate of removing it.
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Underlying Medical Conditions:
- Hyperthyroidism: An overactive thyroid (hyperthyroidism) can sometimes lead to elevated HDL cholesterol.
It is important to consult with your doctor to determine the specific cause of your high HDL levels and whether any intervention is necessary. While high HDL is generally considered cardioprotective, extremely high levels (especially those caused by genetic mutations) might not always confer the same benefits and may even be associated with adverse health outcomes in some cases. Further investigation may be warranted.
