Venom primarily hates Spider-Man.
Venom's hatred for Spider-Man stems from the belief that Spider-Man (Peter Parker) is the source of his misfortunes. The symbiote initially bonded with Peter Parker, who later rejected it. This rejection, combined with Spider-Man's perceived role in the symbiote's perceived humiliation, fueled a deep-seated resentment. Furthermore, Venom, especially when bonded with Eddie Brock, sees Spider-Man as a rival and obstacle. Venom is generally depicted as bigger, stronger, and often more ruthless than Spider-Man, further fueling this animosity.
