Preventing Cytokine Release Syndrome (CRS), a systemic inflammatory response, involves strategies focused on mitigating its risk during immunotherapies like CAR-T cell therapy.
Currently, complete prevention of CRS isn't always possible, but managing and reducing the risk is achieved through several strategies:
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Next-Generation CAR-T Therapies: The reference mentions the development of newly designed next-generation CAR-T treatments for both hematopoietic malignancies and solid tumors to reduce the risk of CRS. These therapies aim to be more targeted and controlled, lessening the inflammatory response.
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Immunosuppressants: While not preventative in the strictest sense, immunosuppressants such as tocilizumab are currently administered to treat the onset and progression of CRS symptoms, as noted in the reference. Early administration of these medications can help to manage and control the severity of CRS.
| Strategy | Description | Preventative? | Reference Information |
|---|---|---|---|
| Next-Generation CAR-T Therapies | Designing CAR-T therapies that are less likely to induce a strong inflammatory response. | Yes, ideally | "...newly designed next-generation CAR-T treatments are being developed...to reduce the risk of CRS..." |
| Immunosuppressants | Administering drugs like tocilizumab to manage the inflammatory response early. | Not directly | "Immunosuppressants such as tocilizumab are currently administered to treat the onset and progression of CRS symptoms" |
It's important to note that research is ongoing to further refine preventative strategies. The future may see more targeted and effective methods for completely preventing CRS.
