Elevated albumin levels in cerebrospinal fluid (CSF) can be caused by a lesion in the choroid plexus or a blockage in the flow of CSF.
Here's a more detailed breakdown:
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Lesion in the Choroid Plexus: The choroid plexus is responsible for producing CSF. Damage or dysfunction in this area can lead to increased albumin production and subsequently, higher levels in the CSF.
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Blockage in CSF Flow: Obstructions within the pathways that CSF flows through can cause a buildup of protein, including albumin. This occurs because the normal removal of albumin from the CSF is impaired. These blockages can be caused by:
- Tumors
- Inflammation
- Scarring from previous infections or surgeries
In addition to these primary causes, high normal albumin levels in CSF may also be associated with degenerative neurological conditions such as:
- Cerebral or cerebellar atrophy
- Amyotrophic lateral sclerosis (ALS)
- Brain tumors
It is important to note that normal albumin levels can sometimes be found in cases of incomplete obstruction of the spinal canal. Further investigation is usually needed to determine the exact cause of elevated albumin in CSF.
