The provided information doesn't define "macules syndrome." Macules themselves are flat, hyperpigmented skin lesions, like cafe-au-lait macules (CALMs). Therefore, without further context or a more specific medical term, there is no recognized "macules syndrome." If you are looking for information on syndromes associated with multiple macules, that would be a different question. It's possible the question contains a typo, referring to a syndrome characterized by macules as a symptom.
A more precise question would be needed to provide a useful answer.
