The hormone that increases intestinal motility is motilin.
Understanding Motilin's Role in Digestion
Motilin plays a vital role in regulating the movement of the digestive tract, particularly during the fasting state. Here's a breakdown of its function:
- Source: Motilin is released by entero-endocrine cells (specifically Mo cells) located in the upper part of the small intestine.
- Release Trigger: This hormone is cyclically released during periods when the digestive system is empty, or in a fasted state.
- Mechanism of Action: Motilin stimulates muscle contractions in the stomach and small intestine. These contractions propel undigested food and debris through the digestive system toward the large intestine.
How Motilin Affects Digestive Motility
The stimulation of gastric and small intestine motility by motilin is crucial for:
- Clearing the digestive tract: By increasing contractions, motilin helps to move any remaining food or digestive materials through the system.
- Preventing bacterial overgrowth: Regular movement helps to prevent the accumulation of bacteria in the upper digestive tract.
- Preparing for the next meal: By moving any remaining contents toward the large intestine, the digestive tract is prepared to receive and process the next meal.
Practical Insights
- Problems with motility can lead to discomfort and digestive issues. Understanding how hormones like motilin function is essential for diagnosing and treating these conditions.
- Specific medications may target the motilin pathway to help regulate gut motility in patients who suffer from conditions such as gastroparesis, a condition in which the stomach empties too slowly.
| Hormone | Primary Action | Location of Release |
|---|---|---|
| Motilin | Increases gastric and small intestine motility | Entero-endocrine cells (Mo cells) in the upper small intestine |
Motilin is essential for the efficient functioning of the digestive system. It is responsible for ensuring that food and waste move through the gastrointestinal tract, particularly during periods of fasting.
