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Is DNA Hydrophobic or Hydrophilic?

Published in DNA Properties 2 mins read

DNA is hydrophilic.

DNA's Hydrophilic Nature Explained

According to the provided information, DNA is a hydrophilic molecule and carries a negative charge. This means it interacts readily with water. In contrast, the cell membrane, composed primarily of lipids, is hydrophobic, which prevents hydrophilic molecules like DNA from easily crossing it.

Hydrophilic vs. Hydrophobic: Key Differences

Feature Hydrophilic Hydrophobic
Definition "Water-loving"; Attracted to and dissolves in water "Water-fearing"; Repelled by and does not dissolve in water
Polarity Polar or charged Nonpolar
Interaction Forms hydrogen bonds with water Minimizes contact with water
Example DNA, sugars, ions Lipids, oils

Why DNA's Hydrophilic Nature Matters

The hydrophilic nature of DNA is crucial for its function within cells. Since cells are largely water-based environments, DNA's ability to interact favorably with water allows it to be properly solvated and maintain its structure. The fact that the cell membrane is hydrophobic and impedes the crossing of DNA highlights the need for specific transport mechanisms to move DNA into or out of the cell when necessary (e.g., during cell division or genetic transfer).

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