Several drugs are associated with causing Usual Interstitial Pneumonia (UIP), a specific pattern of lung injury. These drugs fall into several categories:
Here's a breakdown of the drug categories and examples:
Drug Categories Associated with UIP
| Category | Examples |
|---|---|
| Antibiotics | Nitrofurantoin, Sulfa drugs |
| Heart Medicines | Amiodarone |
| Chemotherapy | Bleomycin, Cyclophosphamide, Methotrexate |
| Immunotherapy | Immunotherapy drugs used to treat cancer |
| Street Drugs | Various illicit substances |
Detailed Examples
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Antibiotics: Certain antibiotics, like nitrofurantoin (commonly used for urinary tract infections) and sulfa drugs, have been linked to drug-induced lung disease, which can sometimes manifest as UIP.
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Heart Medicines: Amiodarone, a medication used to treat heart arrhythmias, is a well-known cause of pulmonary toxicity, including UIP.
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Chemotherapy Drugs: Several chemotherapy agents can cause lung damage. Examples include:
- Bleomycin: Often used in cancer treatment, especially for lymphomas and testicular cancer.
- Cyclophosphamide: Used in treating various cancers and autoimmune diseases.
- Methotrexate: Used for cancer, autoimmune conditions, and ectopic pregnancies.
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Immunotherapy Drugs: These medications, designed to boost the immune system to fight cancer, can sometimes cause immune-related adverse events, including lung inflammation and UIP.
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Street Drugs: The specific street drugs linked to UIP are variable and often difficult to pinpoint due to poly-substance abuse and inconsistent drug composition.
Important Note: This is not an exhaustive list, and other medications can potentially contribute to UIP. If you are concerned about a medication you are taking, consult your doctor.
