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Does the Liver Produce Insulin?

Published in Endocrine System 1 min read

No, the liver does not produce insulin. Insulin is a hormone produced by the beta cells in the pancreas. The liver plays a crucial role in regulating blood sugar levels, but it does not create insulin itself.

While the liver doesn't produce insulin, it is involved in the process of glucose regulation in several ways:

  • Insulin's action on the liver: Insulin acts on the liver to increase glucose uptake, decrease gluconeogenesis (the process of creating glucose from other sources), and promote glycogen synthesis (storing glucose as glycogen).
  • Liver's glucose sensing machinery: The liver contains a glucose sensing machinery similar to pancreatic beta cells, enabling it to respond to changes in blood glucose levels.
  • Insulin degradation: The liver is responsible for degrading a significant portion of the insulin secreted by the pancreas.

Although the liver doesn't produce insulin, it is essential for proper glucose regulation and plays a vital role in the body's response to insulin.

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