The concept of "largest hormone" is misleading. Hormones are not measured by size but by their biological effects and functions. Instead of focusing on physical size, it's more accurate to consider the largest endocrine organ, which is responsible for producing and secreting a wide range of hormones. This title belongs to the gut, also known as the gastrointestinal tract.
The gut houses over 30 hormone genes and produces numerous bioactive peptides, making it a crucial player in various bodily functions. While the thyroid gland is the largest individual endocrine gland, the gut's vast surface area and diverse hormonal output solidify its position as the largest endocrine organ.
