Several factors and conditions can reduce Alkaline Phosphatase (ALP) levels. According to the provided reference, these include:
- Low phosphate levels
- Zinc or magnesium deficiency
- Postmenopausal women receiving oestrogen replacement
- Hypothyroidism (an underactive thyroid)
- Severe anaemia
- Wilson's disease (an inherited disorder that causes copper to accumulate in the organs)
- The oral contraceptive pill
Here's a breakdown of each factor:
Factors That Decrease ALP
| Factor | Description |
|---|---|
| Low Phosphate Levels | Hypophosphatemia, or low phosphate in the blood, can decrease ALP activity. |
| Zinc or Magnesium Deficiency | These minerals are important cofactors for many enzymes, including ALP; deficiency can impair enzyme function. |
| Postmenopausal Women (Oestrogen) | Oestrogen replacement therapy in postmenopausal women is associated with decreased ALP levels. |
| Hypothyroidism | An underactive thyroid can result in reduced metabolic activity and lower levels of various enzymes, including ALP. |
| Severe Anaemia | Severe anaemia can impact various bodily functions, potentially leading to a reduction in ALP levels. |
| Wilson's Disease | This condition leads to copper accumulation, which can interfere with enzyme production and function, including ALP. |
| The Oral Contraceptive Pill | The hormones in oral contraceptives can affect liver enzyme levels, including ALP. |
