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What is PLP in biochemistry?

Published in Enzymes & Cofactors 1 min read

PLP in biochemistry stands for pyridoxal 5'-phosphate, a crucial cofactor.

Pyridoxal 5'-phosphate (PLP) is a vital molecule in biochemistry, acting primarily as a coenzyme. Here's a breakdown:

  • Definition: Pyridoxal 5'-phosphate (PLP) is the active form of vitamin B6.

  • Function: It serves as an essential cofactor for numerous enzymes.

  • Role: These enzymes are primarily involved in the metabolism of amine-containing natural products. This includes:

    • Amino acids
    • Amino-sugars

In simpler terms, PLP helps enzymes process molecules that contain amine groups (a nitrogen atom bonded to hydrogens or carbons). Vitamin B6 must be converted into PLP to be utilized by the body.

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