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What is Miosis and Mydriasis?

Published in Eye Physiology 3 mins read

Miosis and mydriasis refer to the opposing actions of the pupil in the eye.

Understanding Pupil Changes

The pupil, the black center of your eye, naturally changes in size to control the amount of light entering the eye. These changes are governed by the muscles of the iris.

Miosis: Pupil Constriction

Miosis, also known as myosis, describes the excessive constriction of the pupil. This means the pupil becomes smaller, reducing the amount of light that can enter the eye.

  • Etymology: The word miosis originates from the Ancient Greek word mĂșein, meaning "to close the eyes," which directly relates to the pupil becoming smaller.

Mydriasis: Pupil Dilation

Mydriasis is the opposite of miosis, defined as the dilation of the pupil. This results in a larger pupil, allowing more light to enter the eye.

Key Differences

Here's a table summarizing the key differences between miosis and mydriasis:

Feature Miosis Mydriasis
Pupil Size Constricts (becomes smaller) Dilates (becomes larger)
Light Entry Decreased Increased
Cause Can be a reaction to bright light, certain medications, or certain medical conditions Can be a reaction to dim light, emotional states, certain medications, or certain medical conditions

Factors Influencing Pupil Size

Several factors can cause the pupil to change size:

  • Light: In bright environments, pupils constrict (miosis) to limit the amount of light reaching the retina. In dim light, pupils dilate (mydriasis) to allow more light in, improving vision in darkness.
  • Medications: Certain drugs can cause either miosis or mydriasis as a side effect. For example, opioid medications often cause miosis while some antidepressants or antihistamines cause mydriasis.
  • Emotions and Physiological States: In response to stress, fear, or attraction, the pupils can dilate (mydriasis). This is due to the autonomic nervous system influencing the iris muscles.
  • Medical Conditions: Certain medical conditions, such as Horner's syndrome, can cause one pupil to be smaller than the other (miosis) or one to be larger (mydriasis).

Clinical Significance

Understanding miosis and mydriasis is crucial in medical contexts. Pupil response is routinely checked during neurological exams as it can indicate underlying conditions or reactions to medications. Abnormal pupil size or reaction can signal:

  • Neurological problems.
  • Drug use or overdose.
  • Eye injury or inflammation.

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