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What is the difference between fatty acid biosynthesis and degradation?

Published in Fatty Acid Metabolism 1 min read

Fatty acid biosynthesis and degradation are opposing metabolic processes with distinct locations, carriers, and overall goals.

Here's a breakdown of the key differences:

Location

One of the primary distinctions lies in the cellular location where these processes occur:

  • Fatty Acid Biosynthesis: Takes place in the cytosol.
  • Fatty Acid Degradation: Takes place in the mitochondrion.

Carrier Molecules

Another key difference is the molecule that carries the fatty acyl chain:

  • Fatty Acid Biosynthesis: The acyl carrier protein, or ACP, carries the fatty acyl chain.
  • Fatty Acid Degradation: The fatty acyl chain is attached to CoA.

Summary Table

Feature Fatty Acid Biosynthesis Fatty Acid Degradation (Beta-Oxidation)
Location Cytosol Mitochondrion
Carrier ACP (Acyl Carrier Protein) CoA
Overall Goal Synthesize fatty acids Break down fatty acids

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