Cloud primarily fights Sephiroth, his archenemy, throughout the Final Fantasy VII series.
Beyond Sephiroth, Cloud also faces numerous other enemies. These include:
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Shinra Electric Power Company: Initially, Cloud and his allies work against Shinra, a powerful corporation draining the planet's resources. He confronts various Shinra soldiers, robots, and executives.
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Various Monsters and Creatures: As part of his mercenary work and journey, Cloud battles a wide array of monsters found in the game world, ranging from common enemies to powerful bosses.
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SOLDIER Members (Other): He also encounters and fights other members of SOLDIER, particularly those loyal to Shinra or who have become corrupted by Mako energy.
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Reeve/Cait Sith (Sometimes): Cloud occasionally finds himself in conflict with Reeve Tuesti, often manifested through his robotic cat, Cait Sith, due to differing objectives or misunderstandings.
However, the most iconic and pivotal conflicts are undoubtedly those against Sephiroth, who is the central antagonist driving the narrative. The struggle against Sephiroth is both physical and psychological, deeply influencing Cloud's identity and actions.