No, Gi decreases cAMP levels.
How Gi Affects cAMP
The reference states that the activation of the Gi family of proteins inhibits adenylyl cyclase (AC) activity, which decreases cAMP levels. Elevated cAMP levels typically activate cAMP-dependent protein kinases, propagating a signaling cascade. Gi essentially works in the opposite direction.
| Protein Family | Effect on Adenylyl Cyclase (AC) | Effect on cAMP Levels |
|---|---|---|
| Gi | Inhibits | Decreases |
| Other G proteins (e.g., Gs) | Stimulates | Increases |
In summary, Gi activation leads to a reduction, not an increase, in intracellular cAMP concentrations.
