ECL-like cells in the stomach secrete histamine.
Histamine and ECL-like Cells: A Closer Look
The reference material indicates that ECL-like cells, primarily located in the fundus of the stomach, are responsible for producing and secreting histamine. This process is triggered by gastrin, a hormone that indirectly increases HCl production. Histamine directly acts on parietal cells, stimulating them to produce stomach acid.
Key Takeaways
- ECL-like cells: These are the histamine-producing cells.
- Location: Primarily found in the fundus of the stomach.
- Stimulus: Gastrin stimulates histamine release.
- Action: Histamine directly stimulates parietal cells to produce HCl (stomach acid).
