Domperidone is primarily used to treat nausea and vomiting. It achieves this by affecting the muscles in the stomach, promoting better movement and reducing the likelihood of vomiting. However, its uses extend beyond this core function.
Key Uses of Domperidone:
- Treating Nausea and Vomiting: This is the most common use of domperidone. It's effective in relieving the discomfort associated with nausea and vomiting caused by various conditions. [Source: Drugs.com, Mayo Clinic, NHS]
- Improving Breast Milk Supply: In some cases, domperidone is prescribed off-label to increase breast milk production in breastfeeding mothers. [Source: The Women's, Children's Health Queensland]
- Treating Gastrointestinal Issues: Domperidone can be used to help with symptoms of slowed stomach emptying, a condition sometimes seen in certain gastrointestinal disorders. [Source: Health Products and Food Branch Canada]
Important Considerations:
- FDA Approval: It's crucial to note that domperidone is not FDA-approved for use in the United States. Its availability and use vary by country. [Source: FDA]
- Short-Term Use: In many instances, domperidone is recommended for short-term use only due to potential long-term side effects. [Source: GOV.UK]
- Cardiac Side Effects: There is a potential risk of cardiac side effects associated with domperidone use, highlighting the importance of consulting a doctor before taking it. [Source: GOV.UK]
- Off-Label Use: The use of domperidone for increasing breast milk supply is considered off-label, meaning it's not the officially approved use for the drug. [Source: The Women's]
Domperidone's mechanism of action involves acting as a dopamine receptor antagonist. It stimulates the movement of the stomach and intestines (peristalsis) to alleviate symptoms of dyspepsia, indigestion, and epigastric pain. [Source: DrugBank] However, the effectiveness for treating gastroesophageal reflux (GOR) in young children is not robustly supported by evidence. [Source: PubMed]
