A Krab gene is one that codes for a zinc-finger transcription factor containing a Krüppel-associated box (KRAB) domain.
Understanding Krab Genes
The Krab domain is significant because it functions as a transcriptional repressor, meaning it can turn off or reduce the expression of other genes. These proteins also contain C2H2 zinc-finger motifs, which bind to DNA, allowing the protein to attach to specific regions of the genome. Therefore, Krab genes are involved in regulating gene expression.
Key Features of Krab Genes
- Zinc-Finger Transcription Factors: They belong to the largest family of zinc-finger transcription factors.
- KRAB Domain: The presence of the KRAB domain defines these proteins. The Krab domain acts as a transcriptional repressor domain.
- DNA Binding: The C2H2 zinc-finger motifs enable these proteins to bind to DNA.
Function
The primary function of Krab genes is to control the expression of other genes by binding to specific DNA sequences. These proteins play critical roles in various cellular processes, including development and differentiation.
