Yes, an individual with XXY chromosomes is still considered male.
Understanding XXY Chromosomes
Usually, a female has two X chromosomes (XX), and a male has one X and one Y chromosome (XY). The presence of a Y chromosome is the determining factor for maleness. However, in Klinefelter syndrome, a genetic condition, a male is born with an extra X chromosome, resulting in an XXY chromosomal makeup. Despite the extra X chromosome, the presence of the Y chromosome signifies that the individual is genetically male. [Source: Numerous sources cited below confirm this.]
Several reputable medical sources confirm this:
- NHS: States that Klinefelter syndrome (XXY) affects "boys and men." https://www.nhs.uk/conditions/klinefelters-syndrome/
- MedlinePlus Genetics: Clearly states that Klinefelter syndrome affects "people who are assigned male at birth." https://medlineplus.gov/genetics/condition/klinefelter-syndrome/
- Nemours KidsHealth: Specifies that Klinefelter syndrome (XXY syndrome) is "a fairly common genetic condition found in males only." https://kidshealth.org/en/parents/klinefelter-syndrome.html
- Mayo Clinic: Indicates that Klinefelter syndrome occurs when a "person assigned male at birth has an extra copy of the X sex chromosome." https://www.mayoclinic.org/diseases-conditions/klinefelter-syndrome/symptoms-causes/syc-20353949
- Wikipedia: Describes Klinefelter syndrome as a "chromosome anomaly where a male has an extra X chromosome." https://en.wikipedia.org/wiki/Klinefelter_syndrome
- Research Article (NCBI): Explicitly states that individuals with a normal Y chromosome and multiple X chromosomes (such as XXY) are still males. https://pmc.ncbi.nlm.nih.gov/articles/PMC7362088/
While Klinefelter syndrome can lead to certain developmental differences, it does not change the genetic sex of the individual. The presence of the Y chromosome remains the defining characteristic of a male.
